Metabolism. 1983;32:52-56. 92. Lefebvre PJ, Luyckx AS. Effect of insulin on glucagon enhanced lipolysis in vitro. Diabetologia. 1969;5:195-197. 93. Jensen MD, Caruso M, Heiling V, et al. Insulin regulation of lipolysis in nondiabetic and IDDM subjects. Diabetes. 1989;38:1595-1601. 94. Howard BV, Savage PJ, Nagulesparan M, et al. Evidence for marked sensitivity to the antilipolytic action of insulin in obese maturity-onset diabetics.
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 It may also act peripherally by increasing thermogenesis and therefore increasing energy expenditure.  Weight loss with Rimonabant however has not been shown to be greater than other available weight-loss medication.  Due to safety concerns, primarily psychiatric in nature, the drug has not received approval in the United States or Canada, either as an anti-obesity treatment or as a smoking-cessation drug.[ citation needed ] Sanofi-Aventis has received approval to market Rimonabant as a prescription anti-obesity drug in the European Union, subject to some restrictions.[ citation needed ] However, in October 2008, the European Medicines Agency (EMEA) recommended that Acomplia no longer be available in UK.[ citation needed ] One month later, Sanofi-Aventis decided it would no longer study rimonabant for any indication.[ clarification needed ] Metformin[ edit ] In people with Diabetes mellitus type 2 , the drug metformin (Glucophage) can reduce weight.
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